Induction of Oxidative Stress in the Epididymis of Rats After Subchronic Exposure to Epichlorohydrin

被引：2

作者：

Shin, In-Sik ^{[1
]}

Lim, Jeong-Hyeon ^{[1
]}

Kim, Sung-Hwan ^{[1
]}

Kim, Kang-Hyeon ^{[1
]}

Park, Na-Hyeong ^{[1
]}

Bae, Chun-Sik ^{[1
]}

Kang, Seong-Soo ^{[1
]}

Moon, Changjong ^{[1
]}

Kim, Sung-Ho ^{[1
]}

Jun, Woojin ^{[2
]}

Kim, Jong-Choon ^{[1
]}

机构：

[1] Chonnam Natl Univ, Anim Med Ctr, Coll Vet Med, Kwangju 500757, South Korea

[2] Chonnam Natl Univ, Dept Food & Nutr, Kwangju 500757, South Korea

来源：

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY | 2010年 / 84卷 / 06期

关键词：

Epichlorohydrin; Reproductive dysfunction; Sperm; Oxidative stress; ALPHA-CHLOROHYDRIN; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; SUPEROXIDE-DISMUTASE; HUMAN-SPERMATOZOA; PHOSPHOLIPIDS; GLUTATHIONE; FERTILITY; ORGANS;

D O I：

10.1007/s00128-010-0018-9

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This study investigated the effects of epichlorohydrin (ECH) on spermatogenesis and antioxidant system in rats. An increase in the incidence of clinical signs, gross pathology and histopathology findings in the epididymidis, and sperm abnormalities and a decrease in the testicular spermatid counts, epididymal sperm counts, and sperm motility were observed at 30 mg/kg/day. Oxidative stress in the epididymal tissue was detected at a parts per thousand yen3.3 mg/kg/day. The results show that graded doses of ECH elicit depletion of antioxidant defense system and that the adverse effects on male reproductive function in ECH-treated rats may be due to the induction of oxidative stress.

引用

页码：667 / 671

页数：5

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