Organocatalytic enantioselective Michael addition reactions of fluoromalonates with α,β-unsaturated aldehydes

被引：8
|
作者：
Li Hao [1 ]
Ji YaFei [2 ]
Li Jian [2 ]
Zhang ShiLei [1 ]
Yu ChenGuang [1 ]
Wang Wei [1 ,2 ]
机构：
[1] Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA
[2] E China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Sci, Shanghai 200237, Peoples R China
来源：
SCIENCE CHINA-CHEMISTRY | 2010年 / 53卷 / 01期
关键词：
organocatalysis; alpha; beta-unsaturated aldehydes; chiral fluorinated compounds; Michael addition; CARBONYL-COMPOUNDS; ASYMMETRIC FLUORINATION; ALPHA-FLUOROKETONES; CONJUGATE ADDITION; CINCHONA ALKALOIDS; BETA-KETOESTERS; CATALYSIS; STRATEGIES; ETHERS; HALOGENATION;
D O I：
10.1007/s11426-010-0031-1
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new organocatalytic enantioselective Michael addition of alpha-fluoromalonate to enals has been developed. The process is efficiently catalyzed by readily available chiral diphenylpyrolinol TES ether under mild reaction conditions to afford versatile highly enantioenriched fluorinated aldehydes.
引用
收藏
页码：135 / 139
页数：5
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