Immunotherapy in Pediatric Solid Tumors-A Systematic Review

被引:12
|
作者
Marayati, Raoud [1 ]
Quinn, Colin H. [1 ]
Beierle, Elizabeth A. [1 ]
机构
[1] Univ Alabama Birmingham, Dept Surg, Div Pediat Surg, Birmingham, AL 35294 USA
基金
美国国家卫生研究院;
关键词
pediatric solid tumors; immunotherapy; chimeric antigen receptors; cancer vaccines; oncolytic viral therapy; immune checkpoint inhibitors; immunomodulation; STEM-CELL TRANSPLANTATION; CYTOKINE RELEASE SYNDROME; COLONY-STIMULATING FACTOR; NECROSIS-FACTOR-ALPHA; NATURAL-KILLER-CELLS; MODIFIED T-CELLS; PHASE-II TRIAL; ANTIGEN RECEPTOR; MURAMYL TRIPEPTIDE; ANTITUMOR-ACTIVITY;
D O I
10.3390/cancers11122022
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Despite advances in the treatment of many pediatric solid tumors, children with aggressive and high-risk disease continue to have a dismal prognosis. For those presenting with metastatic or recurrent disease, multiple rounds of intensified chemotherapy and radiation are the typical course of action, but more often than not, this fails to control the progression of the disease. Thus, new therapeutics are desperately needed to improve the outcomes for these children. Recent advances in our understanding of both the immune system's biology and its interaction with tumors have led to the development of novel immunotherapeutics as alternative treatment options for these aggressive malignancies. Immunotherapeutic approaches have shown promising results for pediatric solid tumors in early clinical trials, but challenges remain concerning safety and anti-tumor efficacy. In this review, we aim to discuss and summarize the main classes of immunotherapeutics used to treat pediatric solid tumors.
引用
收藏
页数:18
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