Ageing and reproduction: is polycystic ovary syndrome an exception?

被引:11
|
作者
Vulpoi, C.
Lecomte, C.
Guilloteau, D.
Lecomte, P.
机构
[1] Univ Hosp Bretonneau, Endocrine Unit, F-37047 Tours 1, France
[2] Univ Med GrTPopa, Dept Endocrinol, Iasi 700111, Romania
[3] Univ Hosp Bretonneau, Fertil Ctr, F-37047 Tours, France
关键词
ageing; fertility; induction of ovulation; PCOS; spontaneous pregnancy;
D O I
10.1016/j.ando.2006.12.005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background. - Polycystic ovary syndrome (PCOS) is a frequent cause of infertility. Despite an impressive number of reports, few have evaluated the influence of age upon fertility. We present the outcomes of three infertile women with PCOS who achieved spontaneous pregnancies when ageing. Case reports. - Three patients with PCOS were monitored for more than 20 years. PCOS was confirmed by clinical data (oligo/amenorrhoea, infertility, hirsutism), hormonal measures and ovarian ultrasonography. All three infertile patients were treated for several years using numerous ovulation induction protocols with varying responses. When ageing, they gained more regular cycles and spontaneously became pregnant at 39, 40 1/2 and 36 years of age, more than 5 years after induction treatment was stopped, and in spite of increasing weight in each of them. Conclusions. - These clinical observations suggest improved fertility in some PCOS ageing women. The positive impact of ageing on cycle regularisation in PCOS has recently been claimed but the fertility outcome was not evaluated. Ovary ageing results in diminution of the follicular cohort in both normal and PCOS women, associated with decreased inhibin B and anti-mullerian hormone (AMH) levels. Lower inhibin B levels induce FSH enhancement, with a rise in FSH rate per follicle which may determine better follicle maturation, regular and ovulatory cycles in PCOS ageing women. The best proof of this improved fertility was the occurrence of spontaneous pregnancies which never occurred previously. (c) 2007 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码:45 / 50
页数:6
相关论文
共 50 条
  • [31] Polycystic ovary syndrome
    Obermayer-Pietsch, Barbara
    Lerchbaum, Elisabeth
    AUSTRIAN JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 2019, 12 (04): : 170 - 173
  • [32] POLYCYSTIC OVARY SYNDROME
    MICKAN, H
    DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 1982, 107 (04) : 153 - 153
  • [33] Polycystic Ovary Syndrome
    Meier, Renate K.
    NURSING CLINICS OF NORTH AMERICA, 2018, 53 (03) : 407 - +
  • [34] Polycystic Ovary Syndrome
    Mousa, Aya
    Joham, Anju
    Boyle, Jacqueline
    SEMINARS IN REPRODUCTIVE MEDICINE, 2021, 39 (03/04) : 69 - 70
  • [35] Polycystic Ovary Syndrome
    Pereira-Eshraghi, Camila F.
    Vuguin, Patricia P.
    PEDIATRICS IN REVIEW, 2024, 45 (06) : 363 - 365
  • [36] Polycystic ovary syndrome
    Franks, S
    JOURNAL OF THE ROYAL COLLEGE OF PHYSICIANS OF LONDON, 1998, 32 (02): : 111 - 113
  • [37] Polycystic Ovary Syndrome
    Legro, Richard S.
    OBSTETRICS AND GYNECOLOGY, 2018, 131 (06): : E157 - E171
  • [38] Polycystic ovary syndrome
    Macklon, Nick S.
    BMJ-BRITISH MEDICAL JOURNAL, 2011, 343
  • [39] Polycystic Ovary Syndrome
    McCartney, Christopher R.
    Marshall, John C.
    NEW ENGLAND JOURNAL OF MEDICINE, 2016, 375 (01): : 54 - 64
  • [40] Polycystic Ovary Syndrome
    Azziz, Ricardo
    OBSTETRICS AND GYNECOLOGY, 2018, 132 (02): : 321 - 336