Increased Prevalence of Vestibular Loss in Mild Cognitive Impairment and Alzheimer's Disease

被引:27
|
作者
Wei, Eric X. [1 ]
Oh, Esther S. [2 ]
Harun, Aisha [1 ]
Ehrenburg, Matthew [1 ]
Xue, Qian-Li [3 ]
Simonsick, Eleanor [4 ]
Agrawal, Yuri [1 ]
机构
[1] Johns Hopkins Univ, Dept Otolaryngol Head & Neck Surg, Sch Med, 601 N Caroline St, Baltimore, MD 21287 USA
[2] Johns Hopkins Univ, Dept Med, Sch Med, 5200 Eastern Ave,Seventh Floor, Baltimore, MD 21224 USA
[3] Johns Hopkins Univ, Dept Med, Div Geriatr Med & Gerontol, Sch Med, 2024 E Monument St,Suite 2-722, Baltimore, MD 21205 USA
[4] NIA, NIH, 3001 S Hanover St,5th Floor, Baltimore, MD 21225 USA
基金
美国国家卫生研究院;
关键词
Alzheimer's disease; mild cognitive impairment; vestibular system; vestibular function tests; aging; HEAD IMPULSE TEST; EVOKED MYOGENIC POTENTIALS; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; NATIONAL INSTITUTE; HIPPOCAMPAL; DEMENTIA; STIMULATION; RECOMMENDATIONS; DYSFUNCTION;
D O I
10.2174/1567205016666190816114838
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background/Aims: Recent evidence has shown that Alzheimer's Disease (AD) patients have reduced vestibular function relative to healthy controls. In this study, we evaluated whether patients with Mild Cognitive Impairment (MCI) also have reduced vestibular function relative to controls, and compared the level of vestibular impairment between MCI and AD patients. Methods: Vestibular physiologic function was assessed in 77 patients (26 MCI, 51 AD) and 295 matched controls using 3 clinical vestibular tests. The association between vestibular loss and cognitive impairment was evaluated using conditional logistic regression models. Results: Individuals with vestibular impairment had a 3 to 4-fold increased odds of being in the MCI vs. control group (p-values < 0.05). MCI patients had a level of vestibular impairment that was intermediate between controls and AD. Conclusion: These findings suggest a dose-response relationship between vestibular loss and cognitive status, and support the hypothesis that vestibular loss contributes to cognitive decline.
引用
收藏
页码:1143 / 1150
页数:8
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