Modulation of bone remodeling by active vitamin D: its role in the treatment of osteoporosis

被引：8
|
作者：
Ikeda, K
Ogata, E
机构：
[1] Natl Inst Lonev Sci, Dept Geriatr Res, Aichi 4748522, Japan
[2] Japanese Fdn Canc Res, Canc Inst Hosp, Tokyo 1708455, Japan
来源：
MECHANISMS OF AGEING AND DEVELOPMENT | 2000年 / 116卷 / 2-3期
关键词：
active vitamin D; osteoporosis; bone resorption; bone formation;
D O I：
10.1016/S0047-6374(00)00115-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Active vitamin D drugs are used for the treatment of osteoporosis in a number of countries, including Japan. However, their use is controversial. Here, we briefly discuss two issues that are important for understanding the role of active vitamin D (rather than plain vitamin D) in the treatment of osteoporosis: (1) whether or not its skeletal effects are mediated solely through its effects on intestinal calcium absorption in calcium- and vitamin D-replete states, and (2) how it modulates the bone remodeling process. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：103 / 111
页数：9
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