A phase Ila clinical trial combining ALRN-6924 and palbociclib for the treatment of patients with tumours harboring wild -type p53 and MDM2 amplification or MDM2/CDK4 co-amplification

被引:0
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作者
Meric-Bernstam, F. [1 ]
Somaiah, N. [2 ]
DuBois, S. G. [3 ,4 ]
Dumbrava, E. E. Ileana [1 ]
Shapiro, G. I. [4 ]
Patel, M. R. [5 ]
Goel, S. [6 ]
Bauer, T. [7 ]
Pinchasik, D. [8 ]
Annis, A. [9 ]
Aivado, M. [10 ]
Vukovic, V. [11 ]
Saleh, M. [12 ]
机构
[1] Univ Texas MD Anderson Canc Ctr, Invest Canc Therapeut, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Sarcoma Med Oncol, Houston, TX 77030 USA
[3] Dana Farber & Boston Childrens, Pediat Oncol, Boston, MA USA
[4] Dana Farber Canc Inst, Early Drug Dev Ctr, Boston, MA 02115 USA
[5] Florida Canc Specialists & Res Inst, Med Oncol, Sarasota, FL USA
[6] Montefiore Med Ctr, Med Oncol, Eastchester Albert Einstein Canc Ctr, East Campus,Med Pk, New York, NY USA
[7] Sarah Cannon Res Inst, Drug Dev, Nashville, TN USA
[8] Aileron Therapeut Inc, Clin Dev, Cambridge, MA USA
[9] Aileron Therapeut Inc, Res, Watertown, MA USA
[10] Aileron Therapeut Inc, Res & Drug Dev, Watertown, MA USA
[11] Aileron Therapeut Inc, Clin & Med, Watertown, MA USA
[12] Univ Alabama Birmingham, ONeal Comprehens Canc Ctr, Hematol Oncol, Birmingham, AL USA
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中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
475P
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页码:179 / +
页数:2
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