Piltunines A-F from the Marine-Derived Fungus Penicillium piltunense KMM 4668

被引：18
|
作者：
Afiyatullov, Shamil Sh [1 ]
Zhuravleva, Olesya, I [1 ,2 ]
Antonov, Alexandr S. [1 ]
Leshchenko, Elena, V [1 ,2 ]
Pivkin, Mikhail, V [1 ]
Khudyakova, Yuliya, V [1 ]
Denisenko, Vladimir A. [1 ]
Pislyagin, Evgeny A. [1 ]
Kim, Natalya Yu [1 ]
Berdyshev, Dmitrii, V [1 ]
von Amsberg, Gunhild [3 ,4 ]
Dyshlovoy, Sergey A. [1 ,2 ,3 ,4 ]
机构：
[1] Russian Acad Sci, GB Elyakov Pacific Inst Bioorgan Chem, Far Eastern Branch, Prospect 100,Letiya Vladivostoka 159, Vladivostok 690022, Russia
[2] Far Eastern Fed Univ, Sch Nat Sci, Sukhanova St 8, Vladivostok 690000, Russia
[3] Univ Med Ctr Hamburg Eppendorf, Hubertus Wald Tumorzentrum, Dept Oncol Hematol & Bone Marrow Transplantat, Sect Pneumol,Lab Expt Oncol, D-20246 Hamburg, Germany
[4] Univ Hosp Hamburg Eppendorf, Martini Klin Prostate Canc Ctr, D-20246 Hamburg, Germany
来源：
MARINE DRUGS | 2019年 / 17卷 / 11期
基金：
俄罗斯科学基金会;
关键词：
Penicillium piltunense; secondary metabolites; carotane sesquiterpenoids; cytotoxic activity; SUBMARINE SOILS; RESISTANCE; METABOLITE; SEA;
D O I：
10.3390/md17110647
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Six new carotane sesquiterpenoids piltunines A-F (1-6) together with known compounds (7-9) were isolated from the marine-derived fungus Penicillium piltunense KMM 4668. Their structures were established using spectroscopic methods. The absolute configurations of 1-7 were determined based on circular dichroism (CD) and nuclear Overhauser spectroscopy (NOESY) data as well as biogenetic considerations. The cytotoxic activity of some of the isolated compounds and their effects on regulation of reactive oxygen species (ROS) and nitric oxide (NO) production in lipopolysaccharide-stimulated macrophages were examined.
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页数：12
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