Putting Glioblastoma in Its Place: IRF3 Inhibits Invasion

被引：3

作者：

Pattwell, Siobhan S. ^{[1
]}

Holland, Eric C. ^{[1
,2
,3
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Human Biol Div, 1124 Columbia St, Seattle, WA 98104 USA

[2] Fred Hutchinson Canc Res Ctr, Seattle Tumor & Translat Res, 1124 Columbia St, Seattle, WA 98104 USA

[3] Univ Washington, Sch Med, Dept Neurol Surg, Alvord Brain Tumor Ctr, Seattle, WA 98195 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2017年 / 23卷 / 09期

基金：

美国国家卫生研究院;

关键词：

SUBTYPES; GLIOMA;

D O I：

10.1016/j.molmed.2017.07.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

With an unsurpassed capacity for invasion into normal brain tissue, glioblastoma multiforme is the most lethal primary brain tumor. New research suggests that altering a subset of extracellular matrix factors, including interferon regulatory factor (IRF)3 and casein kinase (CK)2, may decrease the migratory potential of these aggressive tumors.

引用

页码：773 / 776

页数：5

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