4-Hydroxy-3-carboxycoumarin as an efficient building block for new ruthenium(II) complexes: synthesis, characterization, antibacterial, antioxidant and anti-inflammatory activities

被引：3
|
作者：
Al-Ayed, Abdullah Sulaiman [1 ]
机构：
[1] Qassim Univ, Coll Arts & Sci, Dept Chem, POB 53, Buraydah 51477, Saudi Arabia
来源：
APPLIED ORGANOMETALLIC CHEMISTRY | 2017年 / 31卷 / 05期
关键词：
4-hydroxy-3-carboxycoumarin; antibacterial activity; anti-inflammatory activity; antioxidant activity; Knoevenagel condensation; ruthenium(II) complexes; TRANSFER RADICAL POLYMERIZATION; NITROGEN-CONTAINING LIGANDS; RING-OPENING-METATHESIS; SCHIFF-BASE; CATALYTIC-ACTIVITY; ANTIMICROBIAL ACTIVITY; METAL-COMPLEXES; COUMARIN; SPECTRA;
D O I：
10.1002/aoc.3605
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new 4-hydroxy-3-carboxycoumarin ligand and its ruthenium(II) complexes (1-5) have been synthesized, characterized and screened for their in vitro antibacterial activity against a range of Gram-positive and Gram-negative bacteria. In addition, compounds 1-5 were investigated for antioxidant activities using superoxide radical, 2,2-diphenyl-1-picrylhydrazyl radical and hydroxyl radical scavenging assays, in which most of them displayed significant antioxidant activities. Furthermore, compounds 1-5 were evaluated for anti-inflammatory activity using indirect haemolytic and lipoxygenase inhibition assays and revealed good activity. The new complexes were characterized using spectroscopic methods in addition to elemental analysis.
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页数：8
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