Pharmacological Approaches to the Treatment of Dementia in Down Syndrome: A Systematic Review of Randomized Clinical Studies

被引:4
|
作者
de Oliveira, Laura Cavalcanti [1 ]
de Paula Faria, Daniele [1 ]
机构
[1] Univ Sao Paulo, Dept Radiol & Oncol, Lab Nucl Med LIM43, Fac Med FMUSP, BR-05403911 Sao Paulo, SP, Brazil
来源
MOLECULES | 2022年 / 27卷 / 10期
基金
巴西圣保罗研究基金会;
关键词
down syndrome; trisomy; 21; Alzheimer's disease; dementia; pharmacological treatment; cognitive decline; ALZHEIMERS-DISEASE; VITAMIN-E; DOUBLE-BLIND; INTELLECTUAL DISABILITY; CONTROLLED-TRIAL; DONEPEZIL; MEMANTINE; ADULTS; RIVASTIGMINE; GALANTAMINE;
D O I
10.3390/molecules27103244
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Down Syndrome (DS) is considered the most frequent form of Intellectual Disability, with important expressions of cognitive decline and early dementia. Studies on potential treatments for dementia in this population are still scarce. Thus, the current review aims to synthesize the different pharmacological approaches that already exist in the literature, which focus on improving the set of symptoms related to dementia in people with DS. A total of six studies were included, evaluating the application of supplemental antioxidant therapies, such as alpha-tocopherol; the use of acetylcholinesterase inhibitor drugs, such as donepezil; N-methyl-d-aspartate (NMDA) receptor antagonists, such as memantine; and the use of vitamin E and a fast-acting intranasal insulin. Two studies observed important positive changes related to some general functions in people with DS (referring to donepezil). In the majority of studies, the use of pharmacological therapies did not lead to improvement in the set of symptoms related to dementia, such as memory and general functionality, in the population with DS.
引用
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页数:11
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