Pharmacological Approaches to the Treatment of Dementia in Down Syndrome: A Systematic Review of Randomized Clinical Studies

被引:4
|
作者
de Oliveira, Laura Cavalcanti [1 ]
de Paula Faria, Daniele [1 ]
机构
[1] Univ Sao Paulo, Dept Radiol & Oncol, Lab Nucl Med LIM43, Fac Med FMUSP, BR-05403911 Sao Paulo, SP, Brazil
来源
MOLECULES | 2022年 / 27卷 / 10期
基金
巴西圣保罗研究基金会;
关键词
down syndrome; trisomy; 21; Alzheimer's disease; dementia; pharmacological treatment; cognitive decline; ALZHEIMERS-DISEASE; VITAMIN-E; DOUBLE-BLIND; INTELLECTUAL DISABILITY; CONTROLLED-TRIAL; DONEPEZIL; MEMANTINE; ADULTS; RIVASTIGMINE; GALANTAMINE;
D O I
10.3390/molecules27103244
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Down Syndrome (DS) is considered the most frequent form of Intellectual Disability, with important expressions of cognitive decline and early dementia. Studies on potential treatments for dementia in this population are still scarce. Thus, the current review aims to synthesize the different pharmacological approaches that already exist in the literature, which focus on improving the set of symptoms related to dementia in people with DS. A total of six studies were included, evaluating the application of supplemental antioxidant therapies, such as alpha-tocopherol; the use of acetylcholinesterase inhibitor drugs, such as donepezil; N-methyl-d-aspartate (NMDA) receptor antagonists, such as memantine; and the use of vitamin E and a fast-acting intranasal insulin. Two studies observed important positive changes related to some general functions in people with DS (referring to donepezil). In the majority of studies, the use of pharmacological therapies did not lead to improvement in the set of symptoms related to dementia, such as memory and general functionality, in the population with DS.
引用
收藏
页数:11
相关论文
共 50 条
  • [1] Dementia in Down syndrome: Pharmacological approaches to treatment
    Fleisher, M
    JOURNAL OF INTELLECTUAL DISABILITY RESEARCH, 2000, 44 : 284 - 284
  • [2] The Early Presentation of Dementia in People with Down Syndrome: a Systematic Review of Longitudinal Studies
    Bianca Alexandra Lautarescu
    Anthony John Holland
    Shahid H. Zaman
    Neuropsychology Review, 2017, 27 : 31 - 45
  • [3] The Early Presentation of Dementia in People with Down Syndrome: a Systematic Review of Longitudinal Studies
    Lautarescu, Bianca Alexandra
    Holland, Anthony John
    Zaman, Shahid H.
    NEUROPSYCHOLOGY REVIEW, 2017, 27 (01) : 31 - 45
  • [4] Pharmacological Treatment of Dementia: A Scoping Review of Systematic Reviews
    van de Glind, Esther M. M.
    van Enst, Wynanda A.
    van Munster, Barbara C.
    Rikkert, Marcel G. M. Olde
    Scheltens, Philip
    Scholten, Rob J. P. M.
    Hooft, Lotty
    DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2013, 36 (3-4) : 211 - 228
  • [5] Pharmacological and nonpharmacological approaches to reduce disinhibited behaviors in dementia: a systematic review
    Burley, Claire V.
    Burns, Kim
    Brodaty, Henry
    INTERNATIONAL PSYCHOGERIATRICS, 2022, 34 (04) : 335 - 351
  • [6] Therapeutic approaches for neonatal abstinence syndrome: a systematic review of randomized clinical trials
    Ghazanfarpour, Masumeh
    Najafi, Mona Najaf
    Roozbeh, Nasibeh
    Mashhadi, Mohamadghasem Etemadi
    Keramat-roudi, Atefeh
    Megarbane, Bruno
    Tsatsakis, Aristidis
    Moghaddam, Mohammad Mobin Miri
    Rezaee, Ramin
    DARU-JOURNAL OF PHARMACEUTICAL SCIENCES, 2019, 27 (01) : 423 - 431
  • [7] Therapeutic approaches for neonatal abstinence syndrome: a systematic review of randomized clinical trials
    Masumeh Ghazanfarpour
    Mona Najaf Najafi
    Nasibeh Roozbeh
    Mohamadghasem Etemadi Mashhadi
    Atefeh Keramat-roudi
    Bruno Mégarbane
    Aristidis Tsatsakis
    Mohammad Mobin Miri Moghaddam
    Ramin Rezaee
    DARU Journal of Pharmaceutical Sciences, 2019, 27 : 423 - 431
  • [8] PHARMACOLOGICAL APPROACHES IN THE TREATMENT OF SENILE DEMENTIA
    MARKSTEIN, R
    EUROPEAN NEUROLOGY, 1989, 29 : 33 - 41
  • [9] Long-term randomized clinical trials of pharmacological treatment of obesity: Systematic review
    Castaneda-Gonzalez, Lidia
    Camberos-Solis, Rafael
    Bacardi-Gascon, Montserrat
    Jimenez-Cruz, Arturo
    COLOMBIA MEDICA, 2010, 41 (01): : 17 - 25
  • [10] Capgras Syndrome in Dementia: A Systematic Review of Case Studies
    Margariti, Charikleia
    Mircea, Margareta-Theodora
    CURRENT ALZHEIMER RESEARCH, 2024,