机构:
Beth Israel Deaconess Med Ctr, Div Vaccine Res, Boston, MA 02115 USA
Ragon Inst MGH MIT & Harvard, Boston, MA USABeth Israel Deaconess Med Ctr, Div Vaccine Res, Boston, MA 02115 USA
Barouch, Dan H.
[1
,2
]
Korber, Bette
论文数: 0引用数: 0
h-index: 0
机构:
Los Alamos Natl Lab, Los Alamos, NM USA
Santa Fe Inst, Santa Fe, NM 87545 USABeth Israel Deaconess Med Ctr, Div Vaccine Res, Boston, MA 02115 USA
Korber, Bette
[3
,4
]
机构:
[1] Beth Israel Deaconess Med Ctr, Div Vaccine Res, Boston, MA 02115 USA
Despite more than 2 5 years of concerted worldwide research, the development of a safe and effective HIV-1 vaccine remains elusive. Prototype antibody-based and T cell-based HIV-1 vaccines have failed to show efficacy in clinical trials to date. Next-generation HIV-1 vaccine candidates are in various stages of preclinical and clinical development, but key scientific obstacles pose major challenges for the field. Critical hurdles include the enormous global diversity of the virus and the challenges associated with generating broadly reactive neutralizing antibody and cellular immune responses. We review the current state of the HIV-1 vaccine field and outline strategies that are being explored to overcome these roadblocks.
机构:
Armed Forces Res Inst Med Sci, US Mil HIV Res Program MHRP, USA, Bangkok 10400, ThailandArmed Forces Res Inst Med Sci, US Mil HIV Res Program MHRP, USA, Bangkok 10400, Thailand
Vasan, Sandhya
Michael, Nelson L.
论文数: 0引用数: 0
h-index: 0
机构:
Armed Forces Res Inst Med Sci, US Mil HIV Res Program MHRP, USA, Bangkok 10400, ThailandArmed Forces Res Inst Med Sci, US Mil HIV Res Program MHRP, USA, Bangkok 10400, Thailand
机构:
Southeast Univ, Sch Life Sci & Technol, Key Lab Dev Genes & Human Dis, Nanjing 210096, Peoples R ChinaSoutheast Univ, Sch Life Sci & Technol, Key Lab Dev Genes & Human Dis, Nanjing 210096, Peoples R China
机构:
Fiocruz MS, Inst Oswaldo Cruz, Dept Imunol, Lab AIDS Imunol Mol, BR-21045900 Rio De Janeiro, RJ, BrazilFiocruz MS, Inst Oswaldo Cruz, Dept Imunol, Lab AIDS Imunol Mol, BR-21045900 Rio De Janeiro, RJ, Brazil
Morgado, MG
Guimaraes, ML
论文数: 0引用数: 0
h-index: 0
机构:Fiocruz MS, Inst Oswaldo Cruz, Dept Imunol, Lab AIDS Imunol Mol, BR-21045900 Rio De Janeiro, RJ, Brazil
Guimaraes, ML
Galvao-Castro, B
论文数: 0引用数: 0
h-index: 0
机构:Fiocruz MS, Inst Oswaldo Cruz, Dept Imunol, Lab AIDS Imunol Mol, BR-21045900 Rio De Janeiro, RJ, Brazil
Galvao-Castro, B
MEMORIAS DO INSTITUTO OSWALDO CRUZ,
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