Sustained release and enhanced bioavailability of injectable scutellarin-loaded bovine serum albumin nanoparticles

被引：44

作者：

Wei, Yuanfeng ^{[1
]}

Li, Laicun ^{[1
]}

Xi, Yifeng ^{[1
]}

Qian, Shuai ^{[1
]}

Gao, Yuan ^{[1
]}

Zhang, Jianjun ^{[2
]}

机构：

[1] China Pharmaceut Univ, Sch Tradit Chinese Med, Nanjing 210009, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, Dept Pharmaceut, Nanjing 210009, Jiangsu, Peoples R China

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2014年 / 476卷 / 1-2期

关键词：

Scutellarin; Albumin nanoparticles; Sustained release; Elimination half-life; Bioavailability; DRUG-DELIVERY; CELL LINES; BREVISCAPINE; RATS; PHARMACOKINETICS; DISSOLUTION; PROFILES; DESIGN; BRAIN;

D O I：

10.1016/j.ijpharm.2014.09.038

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this study is to characterize the in-vitro physicochemical and in-vivo pharmacokinetic properties of the scutellarin-loaded bovine serum albumin nanoparticles (STA-BSA-NPs). STA existed as amorphous form in the nanoparticles. Reconstituted STA-BSA-NPs had an average particle size of 283.4 nm and a zeta potential of +17.95 mV. The in-vitro sustained release profile was well fitted with Weibull distribution model. In comparison to STA solution, STA-BSA-NPs exhibited a significantly higher plasma concentration from 20 min to 6 h after intravenous administration to rats. In addition, significantly higher AUC(0-inf) (2.8-fold), prolonged elimination half-life (4.2-fold) and lower clearance (2.7-fold) were achieved. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：142 / 148

页数：7

共 50 条

[21] Sustained release olmesartan medoxomil loaded PLGA nanoparticles with improved oral bioavailability to treat hypertension
Si, Shengyong
Li, Hongman
Han, Xiao
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2020, 55
[22] Design and Development of Sustained Release Vildagliptin-Loaded Silica Nanoparticles for Enhancing Oral Bioavailability
Shirsath, Nitin Rajendra
Goswami, Ajaygiri Kamalgiri
BIONANOSCIENCE, 2021, 11 (02) : 324 - 335
[23] Enhanced protection and bioavailability of Lycium barbarum leaf extract through encapsulation in whey protein isolate and bovine serum albumin nanoparticles
Ni, Zhi-Jing
Liu, Chun-Bo
Xue, Ying
Huang, Hao
Ma, Yi-Long
Thakur, Kiran
Shang, Ya-Fang
Khan, Mohammad Rizwan
Wei, Zhao-Jun
FOOD CHEMISTRY, 2025, 463
[24] Cubic phase nanoparticles for sustained release of ibuprofen: formulation, characterization, and enhanced bioavailability study
Dian, Linghui
Yang, Zhiwen
Li, Feng
Wang, Zhouhua
Pan, Xin
Peng, Xinsheng
Huang, Xintian
Guo, Zhefei
Quan, Guilan
Shi, Xuan
Chen, Bao
Li, Ge
Wu, Chuanbin
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2013, 8 : 845 - 854
[25] Formulation optimization of scutellarin-loaded HP-β-CD/chitosan nanoparticles using response surface methodology with Box–Behnken design
Shanshan Liu
Paul C.Ho
Asian Journal of Pharmaceutical Sciences, 2017, 12 (04) : 378 - 385
[26] Microalgal Bioprocess Toward the Production of Microalgal Oil Loaded Bovine Serum Albumin Nanoparticles
Benan İnan
Didem Özçimen
The Protein Journal, 2021, 40 : 377 - 387
[27] Bovine Serum Albumin Loaded Solid Lipid Nanoparticles Prepared by Double Emulsion Method
LI Zhen
ChemicalResearchinChineseUniversities, 2010, 26 (01) : 136 - 141
[28] Curcumin loaded in bovine serum albumin–chitosan derived nanoparticles for targeted drug delivery
SRIDHAR SKYLAB Rajan
AKILA PANDIAN
TAMILSELVI PALANIAPPAN
Bulletin of Materials Science, 2016, 39 : 811 - 817
[29] Design and development of paclitaxel-loaded bovine serum albumin nanoparticles for brain targeting
Bansal, Amit
Kapoor, Deepak N.
Kapil, Rishi
Chhabra, Neha
Dhawan, Sanju
ACTA PHARMACEUTICA, 2011, 61 (02) : 141 - 156
[30] Preparation and Evaluation of Cabazitaxel-Loaded Bovine Serum Albumin Nanoparticles for Prostate Cancer
Wan, Zhong
Xie, Fangyuan
Wang, Liang
Zhang, Guoqing
Zhang, Hai
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2020, 15 : 5333 - 5344

← 1 2 3 4 5 →