Partitioning of polybrominated diphenyl ethers (PBDEs) in serum and milk from the same mothers

被引:60
|
作者
Schecter, Arnold [1 ]
Colacino, Justin [2 ]
Sjodin, Andreas [3 ]
Needham, Larry [3 ]
Birnbaum, Linda [4 ]
机构
[1] Univ Texas Dallas, Sch Publ Hlth, Dallas, TX 75390 USA
[2] Univ Michigan, Sch Publ Hlth, Ann Arbor, MI 48109 USA
[3] Ctr Dis Control & Prevent, Atlanta, CA USA
[4] NIEHS, NIH, Res Triangle Pk, NC 27709 USA
关键词
PBDE; Partitioning; Milk; Blood; Serum; BROMINATED FLAME RETARDANTS; HIGH-THROUGHPUT EXTRACTION; IN-HOUSE DUST; POLYCHLORINATED-BIPHENYLS; BREAST-MILK; 2,2',4,4',5-PENTABROMODIPHENYL ETHER; DEVELOPMENTAL EXPOSURE; ADIPOSE-TISSUE; CLEANUP METHOD; BLOOD;
D O I
10.1016/j.chemosphere.2009.12.016
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
We and others have previously described partitioning of chemicals, including polychlorinated-p-dioxins, dibenzofurans, and biphenyls in different types of human tissues and fluids, including blood and milk. Additionally, we previously reported the blood to milk partitioning of polybrominated diphenyl ethers (PBDEs) in a group of 11 women. Partitioning is of importance in understanding the toxicokinetics of these compounds and also in clinical medicine in improving estimates of levels in different matrices including blood and milk. In this study we extend these findings, describing the levels of PBDEs detected in the serum and milk of 29 women from Texas. The median sum of the levels of the four most detected congeners (BDE 47, 99, 100, and 153) in serum was 27.8 ng g(-1) lipid (range 6.7-501.6 ng g(-1) lipid). In milk, the median sum of the levels of the same congeners was 39.7 ng g(-1) lipid (range 12.9-580.3 ng g(-1) lipid). The levels detected in breast milk in this study are similar to those we reported in 2003, where a median total PBDE level of 34 ng g-1 lipid was reported. When congener specific blood to milk partitioning ratios were calculated for BDEs 47, 99, 100, and 153, the relatively small tetrabrominated congener, BDE 47, was found in higher concentrations in milk compared to blood, while the higher molecular weight hexabrominated congener, BIDE 153, was found in approximately equal quantities in blood and milk, on a lipid normalized basis. The reason for the differential partitioning of PBDE congeners in milk and blood could be due to variation in toxicokinetics, specifically distribution based on molecular size or molecular weight. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1279 / 1284
页数:6
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