Establishment of Epstein-Barr virus-positive human gastric epithelial cell lines

被引：30
|
作者：
Tajima, M
Komuro, M
Okinaga, K
机构：
[1] Teikyo Univ, Sch Med, Cent Clin Lab, Itabashi Ku, Tokyo 173, Japan
[2] Teikyo Univ, Sch Med, Dept Anat, Itabashi Ku, Tokyo 173, Japan
[3] Teikyo Univ, Sch Med, Dept Surg 2, Itabashi Ku, Tokyo 173, Japan
来源：
JAPANESE JOURNAL OF CANCER RESEARCH | 1998年 / 89卷 / 03期
关键词：
Epstein-Barr virus; gastric carcinoma; cell line; LMP1; EBNA1;
D O I：
10.1111/j.1349-7006.1998.tb00557.x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We have established two Epstein-Barr virus (EBV)-positive cell lines, GT38 and GT39, derived from human gastric tissues of two patients bearing gastric carcinoma. Both cell lines mere positive for cytokeratin, an epithelial marker, but not for lymphocyte-related markers, Unlike GT39 cell line, GT38 cells lacked the property of contact inhibition. EBV genome was detected in both cell lines. The cell lines mere positive for latent membrane protein 1, and EBV-determined nuclear antigen 1 (EBNA1). EBNA2 was also detected in GT38. These cell lines should be useful for studying the interaction of EBV with gastric epithelial cells and its role in gastric carcinogenesis.
引用
收藏
页码：262 / 268
页数：7
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