Microtubule-Associated Protein Mdp3 Promotes Breast Cancer Growth and Metastasis

被引:29
|
作者
Tala [1 ]
Xie, Songbo [1 ]
Sun, Xiaodong [2 ,3 ]
Sun, Xiaoou [1 ]
Ran, Jie [1 ]
Zhang, Linlin [1 ]
Li, Dengwen [1 ]
Liu, Min [1 ]
Bao, Gang [2 ,3 ]
Zhou, Jun [1 ,2 ,3 ]
机构
[1] Nankai Univ, Coll Life Sci, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
[2] Georgia Inst Technol, Dept Biomed Engn, Atlanta, GA 30332 USA
[3] Emory Univ, Atlanta, GA 30332 USA
来源
THERANOSTICS | 2014年 / 4卷 / 10期
基金
中国国家自然科学基金; 美国国家科学基金会;
关键词
breast cancer; cell proliferation; cell motility; growth; metastasis; PACLITAXEL SENSITIVITY; CENTROSOME AMPLIFICATION; SPINDLE MULTIPOLARITY; BINDING PROTEIN; GAMMA-TUBULIN; DYNAMICS; BRCA1; EG5; EB1;
D O I
10.7150/thno.9727
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Breast cancer is the most prevalent cancer in women worldwide with a high mortality rate, and the identification of new biomarkers and targets for this disease is greatly needed. Here we present evidence that microtubule-associated protein (MAP) 7 domain-containing protein 3 (Mdp3) is highly expressed in clinical samples and cell lines of breast cancer. The expression of Mdp3 correlates with clinicopathological parameters indicating breast cancer malignancy. In addition, Mdp3 promotes breast cancer cell proliferation and motility in vitro and stimulates breast cancer growth and metastasis in mice. Mechanistic studies reveal that.-tubulin interacts with and recruits Mdp3 to the centrosome and that the centrosomal localization of Mdp3 is required for its activity to promote breast cancer cell proliferation and motility. These findings suggest a critical role for Mdp3 in the growth and metastasis of breast cancer and may have important implications for the management of this disease.
引用
收藏
页码:1052 / 1061
页数:10
相关论文
共 50 条
  • [21] Microtubule-associated tumor suppressors as prognostic biomarkers in breast cancer
    Sylvie Rodrigues-Ferreira
    Angie Molina
    Clara Nahmias
    Breast Cancer Research and Treatment, 2020, 179 : 267 - 273
  • [22] Microtubule-binding property of microtubule-associated protein 2 differs from that of microtubule-associated protein 4 and tau
    Tokuraku, K
    Katsuki, M
    Matui, T
    Kuroya, T
    Kotani, S
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 1999, 264 (03): : 996 - 1001
  • [23] Microtubule-associated tumor suppressors as prognostic biomarkers in breast cancer
    Rodrigues-Ferreira, Sylvie
    Molina, Angie
    Nahmias, Clara
    BREAST CANCER RESEARCH AND TREATMENT, 2020, 179 (02) : 267 - 273
  • [24] Overexpression of Microtubule-Associated Protein-1 Light Chain 3 Is Associated with Melanoma Metastasis and Vasculogenic Mimicry
    Han, Chunrong
    Sun, Baocun
    Wang, Wei
    Cai, Wenjuan
    Lou, Dan
    Sun, Yan
    Zhao, Xiulan
    TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE, 2011, 223 (04): : 243 - 251
  • [25] Echinoderm microtubule-associated protein like protein 4, a member of the echinoderm microtubule-associated protein family, stabilizes microtubules
    Houtman, S. H.
    Rutteman, M.
    De Zeeuw, C. I.
    French, P. J.
    NEUROSCIENCE, 2007, 144 (04) : 1373 - 1382
  • [26] Classification of the Microtubule-Associated Protein Kinase
    Sheterline, Peter
    BIOCHEMICAL SOCIETY TRANSACTIONS, 1978, 6 : 229 - 230
  • [27] Significance of an autophagy protein, microtubule-associated protein light chain 3 (LC3), in gastric cancer
    Masuda, Go
    Yashiro, Masakazu
    Kasashima, Hiroaki
    Kinoshita, Haruhito
    Fukuoka, Tatsunari
    Morisaki, Tamami
    Hasegawa, Tsuyoshi
    Sakurai, Katsunobu
    Toyokawa, Takahiro
    Kubo, Naoshi
    Tanaka, Hiroaki
    Muguruma, Kazuya
    Ohira, Masaichi
    Chung, Kosei
    CANCER RESEARCH, 2015, 75
  • [28] Arc interacts with microtubules/microtubule-associated protein 2 and attenuates microtubule-associated protein 2 immunoreactivity in the dendrites
    Fujimoto, T
    Tanaka, H
    Kumamaru, E
    Okamura, K
    Miki, N
    JOURNAL OF NEUROSCIENCE RESEARCH, 2004, 76 (01) : 51 - 63
  • [29] APRIL promotes breast tumor growth and metastasis and is associated with aggressive basal breast cancer
    Garcia-Castro, Araceli
    Zonca, Manuela
    Florindo-Pinheiro, Douglas
    Carvalho-Pinto, Carla E.
    Cordero, Alex
    Gutierrez del Burgo, Burgo
    Garcia-Grande, Aranzazu
    Manes, Santos
    Hahne, Michael
    Gonzalez-Suarez, Eva
    Planelles, Lourdes
    CARCINOGENESIS, 2015, 36 (05) : 574 - 584
  • [30] MAP3 - CHARACTERIZATION OF A NOVEL MICROTUBULE-ASSOCIATED PROTEIN
    HUBER, G
    ALAIMOBEURET, D
    MATUS, A
    JOURNAL OF CELL BIOLOGY, 1985, 100 (02): : 496 - 507