Optimization studies on the production of cyclosporin A by solid state fermentation

被引：32
|
作者：
Sekar, C
Balaraman, K
机构：
[1] Malladi Res Ctr, Madras 600097, Tamil Nadu, India
[2] Vector Control Res Ctr, ICMR, Pondicherry 605006, India
来源：
BIOPROCESS ENGINEERING | 1998年 / 18卷 / 04期
关键词：
D O I：
10.1007/s004490050444
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Several parameters including (a) tray fermentation with and without perforation (b) thickness of solid substrate bed (c) type of inoculum (d) size of inoculum (e) effect of relative humidity were studied for the optimum production of Cyclosporin A by solid state fermentation using Tolypocladium sp. The results indicate that while perforations in the trays had no significance on the yield of Cyc A, the other parameters had an influence on the production of Cyc A. The results indicate that under the optimized conditions, Cyc A can be produced in bulk quantities economically.
引用
收藏
页码：293 / 296
页数：4
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