Phyllodes tumors of the breast: A clinicopathological study of 118 cases

The clinical and pathological features of phyllodes tumors of the breast were evaluated through a study of 118 cases: 110 benign tumors, four borderline turners, and four malignant tumors, Local excision was utilized in 105 patients (88%) and radical mastectomy was performed in 10 patients (8%) as the initial treatment. Estrogen receptor (ER) status was positive in se,en (50%) of 14 cases and progesterone receptor (PgR) status was positive in nine (75%) of 12 cases, Local recurrence developed in eight patients, six of those having benign tumors, and two having malignant turners, all of whom were treated by local excision. Of the four patients with malignant tumors, one died of lung and liver metastases 47 months after her first operation, We believe that excision with sufficient free margin may be the treatment of choice for most benign or borderline phyllodes tumors, whereas an Auchincloss modified radical mastectomy or a total glandectomy with lymph node dissection is recommended for patients with malignant tumors, However, a number of problems regarding the treatment of patients with distant metastasis remain yet to be addressed.