Neuroimaging of neuronal circuits involved in tic generation in patients with Tourette syndrome

被引：78
|
作者：
Lerner, A.
Bagic, A.
Boudreau, E. A.
Hanakawa, T.
Pagan, F.
Mari, Z.
Bara-Jimenez, W.
Aksu, M.
Garraux, G.
Simmons, J. M.
Sato, S.
Murphy, D. L.
Hallett, M.
机构：
[1] NIMH, Mol Imaging Branch, Neuropsychol Lab, NIH, Bethesda, MD 20892 USA
[2] NIMH, Mol Imaging Branch, Clin Sci Lab, NIH, Bethesda, MD 20892 USA
[3] NINDS, EEG Sect, NIH, Bethesda, MD 20892 USA
[4] NINDS, Human Motor Control Sect, NIH, Bethesda, MD 20892 USA
来源：
NEUROLOGY | 2007年 / 68卷 / 23期
关键词：
D O I：
10.1212/01.wnl.0000264417.18604.12
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objective: To identify brain regions generating tics in patients with Tourette syndrome using sleep as a baseline. Methods: We used [O-15]H2O PET to study nine patients with Tourette syndrome and nine matched control subjects. For patients, conditions included tic release states and sleep stage 2; and for control subjects, rest states and sleep stage 2. Results: Our study showed robust activation of cerebellum, insula, thalamus, and putamen during tic release. Conclusion: The network of structures involved in tics includes the activated regions and motor cortex. The prominent involvement of cerebellum and insula suggest their involvement in tic initiation and execution.
引用
收藏
页码：1979 / 1987
页数：9
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