Palladium-Catalyzed Enantioselective Narasaka-Heck Reaction/Direct C-H Alkylation of Arenes: Iminoarylation of Alkenes

被引：91

作者：

Bao, Xu ^{[1
]}

Wang, Qian ^{[1
]}

Zhu, Jieping ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Chem Sci & Engn, LSPN, SB,ISIC, BCH 5304, CH-1015 Lausanne, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 32期

基金：

瑞士国家科学基金会;

关键词：

asymmetric catalysis; C-H activation; dihydropyrroles; domino reactions; Narasaka-Heck reactions; C(SP(2))-H BOND ACTIVATION; ASYMMETRIC HECK; EFFICIENT SYNTHESIS; OXIME ESTERS; CYCLIZATION; DERIVATIVES; DIHYDROPYRROLES; 1-AZAAZULENES; AMINATION; ARYLATION;

D O I：

10.1002/anie.201705641

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A palladium-catalyzed reaction of gamma,delta-unsaturated oxime esters with oxadiazoles afforded dihydropyrroles in good to excellent yields through an intramolecular iminopalladation/intermolecular direct heteroarene C-H alkylation cascade. This unprecedented iminoarylation of alkenes was subsequently realized in an enantioselective manner in the presence of a chiral bidentate phosphine ligand (Synphos).

引用

页码：9577 / 9581

页数：5

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