Application of aryloximes as solid-phase ketone linkers

被引：12

作者：

Lepore, SD ^{[1
]}

Wiley, MR ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Corp Ctr, Indianapolis, IN 46285 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 01期

关键词：

D O I：

10.1021/ol026913a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In both solution and the solid phase, a variety of ketone oxime anions have been treated with 4-substituted-2-fluorobenzonitriles to give the corresponding nucleophilic aromatic substitution aryloxime adducts. Under aqueous acidic conditions, these adducts underwent cyclization to give the corresponding ketones. Suzuki and amide coupling reactions were also successfully performed on two resin-bound oximes followed by subsequent cyclorelease to give ketone product in good yields and purities.

引用

页码：7 / 10

页数：4

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