Total synthesis of 2′,4′,6′ -trimethoxy-3′,5′- dimethylchalcone derivatives

被引：1

作者：

Park, Rae Yeon ^{[1
]}

Lee, Hana ^{[1
]}

Park, Kwangyong ^{[1
]}

机构：

[1] Chung Ang Univ, Sch Chem Engn & Mat Sci, 84 Heukseok Ro, Seoul 06974, South Korea

来源：

BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2022年 / 43卷 / 05期

关键词：

2; 4; 6; '-trimethoxy-3; 5; '-dimethylchalcone; antidiabetic compounds; chalcone derivatives; dimethyl cardamonin; total synthesis; FLAVONOIDS; INDUCTION; CHALCONE; 2'; 4'-DIHYDROXY-6'-METHOXY-3'; 5'-DIMETHYLCHALCONE; APOPTOSIS; CELLS;

D O I：

10.1002/bkcs.12515

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC), which is isolated from plants, has recently attracted much attention due to its beneficial pharmacological effects. The preparation of twelve 2',4',6'-trimethoxy-3',5' -dimethylchalcone (DMDMC) derivatives, which are dimethylated-derivatives of DMC, is reported herein for the first time. Our synthetic method allowed the efficient construction of the DMDMC derivatives from phloroglucinol in 37.8%-46.5% overall yields. This promising approach would be advantageous for the production of many different DMDMC derivatives in a short period of time.

引用

页码：731 / 738

页数：8

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