Total synthesis of 2′,4′,6′ -trimethoxy-3′,5′- dimethylchalcone derivatives

2',4'-Dihydroxy-6'-methoxy-3',5'-dimethylchalcone (DMC), which is isolated from plants, has recently attracted much attention due to its beneficial pharmacological effects. The preparation of twelve 2',4',6'-trimethoxy-3',5' -dimethylchalcone (DMDMC) derivatives, which are dimethylated-derivatives of DMC, is reported herein for the first time. Our synthetic method allowed the efficient construction of the DMDMC derivatives from phloroglucinol in 37.8%-46.5% overall yields. This promising approach would be advantageous for the production of many different DMDMC derivatives in a short period of time.