The Cardiovascular Burden in End-Stage Renal Disease

被引：56
|
作者：
Cozzolino, Mario [1 ]
Galassi, Andrea [1 ]
Pivari, Francesca [1 ]
Ciceri, Paola [1 ]
Conte, Ferruccio [1 ]
机构：
[1] Univ Milan, San Paolo Hosp, ASST Santi Paolo & Carlo, Dept Hlth Sci,Renal Div, Milan, Italy
来源：
EXPANDED HEMODIALYSIS: INNOVATIVE CLINICAL APPROACH IN DIALYSIS | 2017年 / 191卷
关键词：
CHRONIC KIDNEY-DISEASE; UREMIC TOXINS; SERUM PHOSPHATE; MORTALITY RISK; FGF23; ATHEROSCLEROSIS; ALBUMINURIA; POPULATION; PHOSPHORUS; EXPRESSION;
D O I：
10.1159/000479250
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
It is well documented that chronic kidney disease patients have an extremely high risk of developing cardiovascular (CV) disease (CVD) compared to the general population. Declining renal function itself represents a continuum of CV risk, and in those individuals who survive to reach end-stage renal disease, the risk of suffering a cardiac event is uncomfortably and unacceptably high. Several pathophysiological pathways have been suggested to account for this, including endothelial dysfunction, dyslipidemia, inflammation, left ventricular hypertrophy, troponins, phosphate, vitamin D, fibroblast growth factor-23, and NT-proBNP. All these conditions and biomarkers may have clear associations with current and subsequent CVD. (c) 2017 S. Karger AG, Basel
引用
收藏
页码：44 / 57
页数：14
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