A Multicomponent One-pot Synthesis of 3-Cyanopyridine Derivatives

被引：0

作者：

Al-Ghorbani, Mohammed ^{[1
,2
]}

Gouda, Moustafa A. ^{[1
,3
]}

Qurban, Jihan ^{[4
]}

机构：

[1] Taibah Univ, Ulla Sci & Arts Coll, Dept Chem, Medina, Saudi Arabia

[2] Thamar Univ, Coll Educ, Dept Chem, Dhamar, Yemen

[3] Mansoura Univ, Fac Sci, Dept Chem, El Gomhoria St, Mansoura, Egypt

[4] Umm Al Qura Univ, Fac Appl Sci, Dept Chem, Mecca, Saudi Arabia

来源：

INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY | 2021年 / 31卷 / 01期

关键词：

3-Cyanopyridine; Malononitrile; Ethyl cyanoacetate; Multicomponent one-pot synthesis; DISCOVERY; INHIBITORS; DESIGN;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient method was developed for synthesis of 2-amino-3-cyanopyridine and 3-cyanopyridine-2(1H)-ones (4a-e, 6a-e) from 2,6-dimethylheptan-4-one, aromatic aldehydes, and malononitrile or ethyl cyanoacetate in the presence of ammonium acetate in good to excellent yields and the structure of targets compounds was characterized by Fourier-transform infrared and H-1 and C-13 nuclear magnetic resonance and mass spectral and elemental analytical data.

引用

页码：77 / 80

页数：4

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