Two Antimicrobial Heterodimeric Tetrahydroxanthones with a 7,7′-Linkage from Mangrove Endophytic Fungus Aspergillus flavus QQYZ

被引：11

作者：

Zang, Zhenming ^{[1
]}

Yang, Wencong ^{[1
]}

Cui, Hui ^{[2
]}

Cai, Runlin ^{[3
]}

Li, Chunyuan ^{[4
]}

Zou, Ge ^{[1
]}

Wang, Bo ^{[1
]}

She, Zhigang ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Peoples R China

[2] Guangzhou Univ Chinese Med, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China

[3] Shantou Univ, Coll Sci, Shantou 515063, Peoples R China

[4] South China Agr Univ, Coll Mat & Energy, Guangzhou 510642, Peoples R China

来源：

MOLECULES | 2022年 / 27卷 / 09期

基金：

中国国家自然科学基金;

关键词：

tetrahydroxanthone dimer; mangrove endophytic fungus; antifungal activities; antibacterial activities; XANTHONE DIMERS; DERIVATIVES; CHIRALITY; FAMILY;

D O I：

10.3390/molecules27092691

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mangrove endophytic fungi represent significant and sustainable sources of novel metabolites with unique structures and excellent biological activities, attracting extensive chemical investigations. In this research, two novel heterodimeric tetrahydroxanthones, aflaxanthones A (1) and B (2), dimerized via an unprecedented 7,7 '-linkage, a sp(3)-sp(3) dimeric manner, were isolated from the mangrove endophytic fungus Aspergillus flavus QQYZ. Their structures were elucidated through high resolution electrospray ionization mass spectroscopy (HRESIMS) and nuclear magnetic resonance (NMR) spectroscopy, the absolute configurations of them were determined by a single-crystal X-ray diffraction combined with calculated electronic circular dichroism (ECD) spectra and a 1D potential energy scan. These compounds were evaluated for antifungal activities in vitro and exhibited broad-spectrum and potential antifungal activities against several pathogenic fungi with minimum inhibitory concentration (MIC) values in the range of 3.13-50 mu M. They also performed moderate antibacterial activities against several bacteria with MIC values in the range of 12.5-25 mu M. This research enriched the resources of lead compounds and templates for marine-derived antimicrobial drugs.

引用

页数：11

共 31 条

[31] Pseurotin A1 and A2, two new 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-diones from the holothurian-derived fungus Aspergillus fumigatus WFZ-25
Wang, Fa-Zuo
Li, De-Hai
Zhu, Tian-Jiao
Zhang, Min
Gu, Qian-Qun
CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE, 2011, 89 (01): : 72 - 76

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