Oral hairy leukoplakia -: Histopathologic and cytopathologic features of a subclinical phase

被引:10
|
作者
Dias, EP
Rocha, ML
Silva, A
Spyrides, KS
Ferreira, SMS
Polignano, GAC
Feijó, EC
Da Fonseca, EC
机构
[1] Univ Fed Fluminense, Dept Pathol, Niteroi, RJ, Brazil
[2] Univ Fed Fluminense, Dept Oral Diag, Niteroi, RJ, Brazil
[3] Univ Fed Rio de Janeiro, Dept Oral Diag, Rio De Janeiro, Brazil
关键词
hairy leukoplakia; subclinical; Epstein-Barr virus; histopathology; cytopathology;
D O I
10.1093/ajcp/114.3.395
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Accurate diagnosis of oral hairy leukoplakia (OHL) is important because it may be an early indicator of undiagnosed HN infection; moreover it may be a prognostic indicator Our purpose,vas to investigate the histopathologic features of subclinical OHL and to evaluate and support the rationale of detecting subclinical OHL with cytopathology. The Epstein-Barr virus (EBV) was detected by immunohistochemistry and in situ hybridization in 4 cases of macroscopically normal lateral borders of tongue mucosa from 8 AIDS necropsies and in none of 8 controls. The histopathologic features were specific when based on nuclear changes: Cowdry type A inclusion, ground glass, and nuclear bending. Smears were obtained from 50 patients with AIDS, without OHL, from the scraping of lateral borders of the tongue. Numerous clusters of the cells were associated with Candida organisms (30% of cases). Nuclear changes were observed in 12 patients (24%) on both sides of the tongue. We describe the histopathologic features of subclinical OHL, and our observations suggest that cytopathology can detect OHL in the subclinical phase.
引用
收藏
页码:395 / 401
页数:7
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