What's So Special about RB?

被引：5
|
作者：
Burd, Christin E. [1 ,2 ]
Sharpless, Norman E. [1 ,2 ,3 ]
机构：
[1] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Dept Genet, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Curriculum Toxicol, Chapel Hill, NC 27599 USA
[3] Univ N Carolina, Sch Med, Lineberger Comprehens Canc Ctr, Dept Med, Chapel Hill, NC 27599 USA
来源：
CANCER CELL | 2010年 / 17卷 / 04期
关键词：
CELLULAR SENESCENCE; EXPRESSION; P130; PRB;
D O I：
10.1016/j.ccr.2010.03.010
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
RB, p107, and p130 are highly related proteins, each capable of regulating cellular proliferation. However, only RB is frequently mutated in cancer. In this issue of Cancer Cell, Chicas et al. shed new light on this conundrum, defining a "special," nonredundant role for RB in promoting cellular senescence.
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页码：313 / 314
页数：2
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