Enantioselective phosphonation of isoquinolines via chiral phosphoric acid-catalyzed dearomatization

被引：11
|
作者：
Gao, Zhenhua [1 ]
Guo, Yongbiao [1 ]
机构：
[1] State Key Lab NBC Protect Civilian, Beijing, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 67期
关键词：
ALPHA-AMINO; HYDROPHOSPHONYLATION; LIGANDS; ROUTE;
D O I：
10.1039/d2cc02811e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient and enantioselective phosphonation protocol for construction of chiral alpha-aminophosphates and alpha-aminodiarylphosphine oxides has been developed based on chiral phosphoric acid-catalyzed dearomatization of isoquinolines. A series of chiral 1,2-dihydroisoquinolines with dimethoxy phosphoryl or diphenylphosphono substituents at the C1-position were constructed with good to excellent yields and enantioselectivities under mild reaction conditions.
引用
收藏
页码：9393 / 9396
页数：4
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