Galectin-3 in Atrial Fibrillation: Mechanisms and Therapeutic Implications

被引：53

作者：

Clementy, Nicolas ^{[1
]}

Piver, Eric ^{[2
]}

Bisson, Arnaud ^{[1
]}

Andre, Clementine ^{[1
]}

Bernard, Anne ^{[1
]}

Pierre, Bertrand ^{[1
]}

Fauchier, Laurent ^{[1
]}

Babuty, Dominique ^{[1
]}

机构：

[1] Francois Rabelais Univ, Trousseau Hosp, Cardiol Dept, F-37000 Tours, France

[2] Francois Rabelais Univ, Trousseau Hosp, Biochem Dept, F-37000 Tours, France

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2018年 / 19卷 / 04期

关键词：

galectin-3; atrial fibrillation; ablation; LATE GADOLINIUM ENHANCEMENT; SMOOTH MUSCLE ACTIN; CATHETER ABLATION; SERUM GALECTIN-3; HEART-FAILURE; MYOCARDIAL-INFARCTION; CLINICAL-OUTCOMES; FIBROSIS; ASSOCIATION; DIFFERENTIATION;

D O I：

10.3390/ijms19040976

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Maintenance of atrial fibrillation is a complex mechanism, including extensive electrical and structural remodeling of the atria which involves progressive fibrogenesis. Galectin-3 is a biomarker of fibrosis, and, thus, may be involved in atrial remodeling in atrial fibrillation patients. We review the role of galectin-3 in AF mechanisms and its potential therapeutic implications.

引用

页数：14

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