Genetics of specific language impairments

被引：6
|
作者：
Bonneau, D
Verny, C
Uzé, J
机构：
[1] CHU Angers, Serv Genet, F-49033 Angers, France
[2] CHU Angers, Serv Neurol, F-49033 Angers, France
[3] Ctr Hosp Henri Laborit, Intersecteur Sud Psychiat Enfant & Adolescent, F-86021 Poitiers, France
来源：
ARCHIVES DE PEDIATRIE | 2004年 / 11卷 / 10期
关键词：
language development disorders; genetics; child;
D O I：
10.1016/j.arcped.2004.03.121
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Specific language impairment (SLI), involving environmental as well as genetic factors, is a complex disorder affecting 5-10% of preschool-age children. This review summarizes current data regarding the genetic factors involved in SLI. Genetic factors were first implicated in SLI on the basis of twin studies and reports of familial cases. Furthermore, several studies have shown that the relative risk of SLI was higher for close relatives of affected individuals. Finally, a specific gene (FOXP2) has been identified on the long arm of chromosome 7 in a family affected with SLI, and several regions of the genome, i.e. 7q3l, 16q and 19q, have been found to be strongly linked to SLI. (C) 2004 Elsevier SAS. Tons droits reserves.
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页码：1213 / 1216
页数：4
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