Natalizumab discontinuation in a Dutch real-world cohort

被引：3
|
作者：
Coerver, E. M. E. [1 ]
Wessels, M. H. J. [1 ]
van Lierop, Z. Y. G. [1 ]
van Kempen, Z. L. E. [1 ]
Killestein, J. [1 ]
Strijbis, E. M. M. [1 ]
机构：
[1] Vrije Univ Amsterdam, MS Ctr Amsterdam, Amsterdam Neurosci, Dept Neurol,Amsterdam Univ Med Ctr, Amsterdam, Netherlands
来源：
MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2021年 / 52卷
关键词：
Multiple sclerosis; Natalizumab; Treatment discontinuation; MS;
D O I：
10.1016/j.msard.2021.102974
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objective: To determine characteristics of multiple sclerosis patients that discontinued natalizumab treatment in a real-world cohort. Methods: Data was collected from an ongoing observational cohort study of all natalizumab treated patients at the Amsterdam UMC. Results: Of 253 patients who ever received natalizumab treatment, 147 have discontinued treatment. The most frequent reason for treatment discontinuation was JC-virus (JCV) positivity. Conclusions: JCV positivity seems the most frequent reason for natalizumab discontinuation. The heterogeneity in treatment switches reflects the advances made in treatment options, and underlines the need for adequate patient counselling.
引用
收藏
页数：3
相关论文
共 50 条
  • [41] Relevant adverse events and drug discontinuation of sacubitril/valsartan in a real-world Japanese cohort: REVIEW-HF registry
    Matsumoto, Shingo
    McMurray, John J. V.
    Nasu, Takahito
    Ishii, Shunsuke
    Kagiyama, Nobuyuki
    Kida, Keisuke
    Fujimoto, Wataru
    Kikuchi, Atsushi
    Ijichi, Takeshi
    Shibata, Tatsuhiro
    Ikeda, Takanori
    Kanaoka, Koshiro
    JOURNAL OF CARDIOLOGY, 2024, 84 (02) : 133 - 140
  • [42] Effect of interruption or discontinuation of endocrine therapy on the prognosis of breast cancer patients: a cohort study using the real-world database
    Huang, Ya
    Chen, Jie
    Wu, Yunhao
    CANCER RESEARCH, 2024, 84 (09)
  • [43] Efficacy and safety of dupilumab as add-on therapy for patients with severe asthma: A real-world Dutch cohort study
    Thelen, John C.
    van Zelst, Cathelijne M.
    van Brummelen, Sigrid E.
    Rauh, Simone
    Kappen, Jasper H.
    in't Veen, Johannes C. C. M.
    Kappen, Jasper H.
    Braunstahl, Gert-Jan
    RESPIRATORY MEDICINE, 2023, 206
  • [44] Real-World Battles with Real-World Data
    Brown, Jeffrey
    Bate, Andrew
    Platt, Robert
    Raebel, Marsha
    Sauer, Brian
    Trifiro, Gianluca
    PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2017, 26 : 254 - 255
  • [45] The Prospective Dutch Colorectal Cancer (PLCRC) Cohort: Towards a unique patient-reported outcome enriched "real-world" data cohort
    Derksen, Jeroen W. G.
    Elferink, Marloes A. G.
    Vink, Geraldine R.
    Roodhart, Jeanine M. L.
    May, Anne Maria
    Koopman, Miriam
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (04)
  • [46] Real-world data on emicizumab prophylaxis in the Milan cohort
    Arcudi, Sara
    Gualtierotti, Roberta
    Marino, Sonia
    Nicolo, Gabriella
    Biguzzi, Eugenia
    Ciavarella, Alessandro
    Boscarino, Marco
    Siboni, Simona Maria
    Schiavone, Lucia
    Novembrino, Cristina
    Valsecchi, Carla
    Peyvandi, Flora
    HAEMOPHILIA, 2022, 28 (05) : E141 - E144
  • [47] A real-world study of Alemtuzumab in a cohort of Italian patients
    Sacca, F.
    Russo, C. V.
    Frau, J.
    Annovazzi, P.
    Signoriello, E.
    Bonavita, S.
    Grasso, R.
    Clerico, M.
    Cordioli, C.
    Laroni, A.
    Capobianco, M.
    Clerici, V. Torri
    Sartori, A.
    Cavalla, P.
    Maniscalco, G. T.
    La Gioia, S.
    Caleri, F.
    Giugno, A.
    Iodice, R.
    Carotenuto, A.
    Cocco, E.
    Fenu, G.
    Zaffaroni, M.
    Baronicini, D.
    Lus, G.
    Gallo, A.
    De Mercanti, S. F.
    Lapucci, C.
    Di Francescantonio, V.
    Sormani, M. P.
    Signori, A.
    MULTIPLE SCLEROSIS JOURNAL, 2019, 25 : 796 - 797
  • [48] A real-world study of alemtuzumab in a cohort of Italian patients
    Russo, Cinzia Valeria
    Sacca, Francesco
    Frau, Jessica
    Annovazzi, Pietro
    Signoriello, Elisabetta
    Bonavita, Simona
    Grasso, Roberta
    Clerico, Marinella
    Cordioli, Cinzia
    Laroni, Alice
    Capobianco, Marco
    Clerici, Valentina Torri
    Sartori, Arianna
    Cavalla, Paola
    Maniscalco, Giorgia Teresa
    La Gioia, Sara
    Caleri, Francesca
    Giugno, Alessia
    Iodice, Rosa
    Carotenuto, Antonio
    Cocco, Eleonora
    Fenu, Giuseppe
    Zaffaroni, Mauro
    Baroncini, Damiano
    Lus, Giacomo
    Gallo, Antonio
    De Mercanti, Stefania Federica
    Lapucci, Caterina
    Di Francescantonio, Valeria
    Brambilla, Laura
    Sormani, Maria Pia
    Signori, Alessio
    EUROPEAN JOURNAL OF NEUROLOGY, 2022, 29 (01) : 257 - 266
  • [49] Real-world effectiveness of natalizumab treatment in patients with relapsing multiple sclerosis in Argentina and Chile
    Ysrraelit, Maria Celica
    Caride, Alejandro
    Sinay, Vladimiro
    Rivera Kindel, Mario
    Halfon, Mario Javier
    Patrucco, Liliana
    Piedrabuena, Raul
    Diaz Aragunde, Vanina Eleonor
    ARQUIVOS DE NEURO-PSIQUIATRIA, 2021, 79 (05) : 407 - 414
  • [50] Exenatide Once Weekly: Effectiveness, Tolerability, and Discontinuation Predictors in a Real-world Setting
    Di Dalmazi, Giulia
    Coluzzi, Sara
    Baldassarre, Maria P. A.
    Sorbo, Sofia Elena
    Dell'Aquila, Stefania
    Febo, Fabrizio
    Ginestra, Federica
    Graziano, Giusi
    Rossi, Maria C.
    Consoli, Agostino
    Formoso, Gloria
    CLINICAL THERAPEUTICS, 2020, 42 (09) : 1738 - +
12345