An efficient stereoselective synthesis of functionalized vinyl ethers

被引：2
|
作者：
Balalaie, Saeed [1 ]
Kassaee, Mohammad Z. [2 ]
Bijanzadeh, Hamid Reza [1 ]
Darvish, Fatemeh [1 ]
Bararjanian, Morteza [1 ]
Jalaiyan, Fatemeh [1 ]
机构：
[1] KN Toosi Univ Technol, Peptide Chem Res Ctr, Tehran, Iran
[2] Tarbiat Modares Univ, Dept Chem, Tehran, Iran
来源：
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY | 2014年 / 11卷 / 05期
基金：
美国国家科学基金会;
关键词：
Functionalized vinyl ethers; Nucleophilic addition to active alkynes; Ugi-4CR; Ugi-4CR post-transformation; N-substituted; 2-alkynamides; SUBSTITUTION; ALCOHOLS; ESTERS;
D O I：
10.1007/s13738-014-0418-6
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient regio and stereoselective synthesis of functionalized E-vinyl ethers are described. The reaction could proceed via addition of primary alcohols and phenols to functionalized N-substituted 2-alkynamides which are produced via Ugi-4CR in the presence of triethylamine at room temperature. The reaction proceeds through sequential Ugi/nucleophilic reaction sequence. High yields, short reaction times, and simple operations are the advantages of this approach.
引用
收藏
页码：1483 / 1492
页数：10
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