Artemisinin tricyclic analogs:: Role of a methyl group at C-5a

被引：18

作者：

Zouhiri, F

Desmaële, D

d'Angelo, J

Riche, C

Gay, F

Cicéron, L

机构：

[1] Univ Paris Sud, Ctr Etud Pharmaceut, Unite Chim Organ, CNRS, F-92296 Chatenay Malabry, France

[2] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

[3] Grp Hosp Pitie Salpetriere, Lab Epidemiol & Chimioresistance Paludisme, Serv Parasitol, F-75651 Paris, France

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 19期

关键词：

antiprotozoals; trioxanes; silicon and compounds; ozonolysis;

D O I：

10.1016/S0040-4039(98)00390-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New artemisinin tricyclic analogs, bearing a methyl group at C-5a were synthetized through ozonation of vinylsilanes. Presence of such a substituent was detrimental to the antimalarial activity of these trioxanes, thus reinforcing the hypothesis that tight hemin-trioxane complexes are involved in the activation phase of these compounds. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2969 / 2972

页数：4

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