Total synthesis of the dolabellane marine diterpenoids, claenone, palominol and dolabellatrienone

被引：21

作者：

Miyaoka, H ^{[1
]}

Isaji, Y ^{[1
]}

Mitome, H ^{[1
]}

Yamada, Y ^{[1
]}

机构：

[1] Tokyo Univ Pharm & Life Sci, Sch Pharm, Hachioji, Tokyo 1920392, Japan

来源：

TETRAHEDRON | 2003年 / 59卷 / 01期

关键词：

antitumour compounds; marine metabolites; terpenes and terpenoids;

D O I：

10.1016/S0040-4020(02)01474-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of marine dolabellane diterpenoids claenone, palominol and dolabellatrienone was conducted from D-mannitol. In each case, formation of the bicyclo[2.2.1]heptane derivative by sequential Michael reaction, preparation of the tetrasubstituted cyclopentane derivative by retro-aldol reaction and cyclization of sulfone were involved as key steps. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：61 / 75

页数：15

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