Marine-derived fungi as a source of bioactive indole alkaloids with diversified structures

被引：23
|
作者：
Meng, Zhi-Hui [1 ]
Sun, Tian-Tian [1 ]
Zhao, Guo-Zheng [1 ]
Yue, Yu-Fei [1 ]
Chang, Qing-Hua [1 ]
Zhu, Hua-Jie [1 ]
Cao, Fei [1 ]
机构：
[1] Hebei Univ, Inst Life Sci & Green Dev, Coll Pharmaceut Sci, Baoding 071002, Peoples R China
来源：
MARINE LIFE SCIENCE & TECHNOLOGY | 2021年 / 3卷 / 01期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
Indole alkaloid; Marine-derived fungus; Chemical diversity; Bioactivity; ENDOPHYTIC FUNGUS; A-C; DIKETOPIPERAZINE DIMER; SECONDARY METABOLITES; CYTOTOXIC CYTOCHALASANS; OXINDOLE ALKALOIDS; DICHOTOMOMYCES-CEJPII; ASPERGILLUS-FLAVUS; NATURAL-PRODUCTS; LEPTOSPHAERIA SP;
D O I：
10.1007/s42995-020-00072-w
中图分类号：
Q17 [水生生物学];
学科分类号：
071004 ;
摘要：
Marine-derived fungi are well known as rich sources of bioactive natural products. Growing evidences indicated that indole alkaloids, isolated from a variety of marine-derived fungi, have attracted considerable attention for their diverse, challenging structural complexity and promising bioactivities, and therefore, indole alkaloids have potential to be pharmaceutical lead compounds. Systemic compilation of the relevant literature. In this review, we demonstrated a comprehensive overview of 431 new indole alkaloids from 21 genera of marine-derived fungi with an emphasis on their structures and bioactivities, covering literatures published during 1982-2019.
引用
收藏
页码：44 / 61
页数：18
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