Effects of quinpirole on operant conditioning: perseveration of behavioral components

Quinpirole (QNP) is reported to elicit repetitive spontaneous behaviors as well as reduce extinction of operant responses. To determine whether these effects represent perseveration of learned behaviors, behavioral components were examined during the acquisition and extinction of operant responses. Rats, receiving either 0, 0.08, or 0.60 mg/kg QNP were trained to nose poke to receive water. The lower dose interfered with acquisition, but once learned, behavioral characteristics were normal. The higher dose produced excessive time in the drinking well when water was delivered. When water was withheld, the control and 0.08 mg/kg dose groups altered their behavior by initially increasing nose poke duration, followed by a progressive extinction of the operant response. The higher dose group, however, did not modify the characteristics of their behaviors, but continued to perform the behavioral sequence in the absence of reward. These effects are not ascribable to generalized locomotor activation in that response rates during reinforced responses, as well as at the beginning of the extinction phase, did not differ significantly across treatment groups. These results indicate that perseveration effects of QNP are not accountable by general behavioral arousal, nor are specific to extinction. Instead, these effects appear to reflect reduced adaptability of learned behavioral patterns to changes in reinforcement contingencies. (C) 2004 Published by Elsevier B.V.