A One-pot, Efficient Synthesis of Polyfunctionalized Pyrido[2,3-d]pyrimidines and Uncyclized Adducts by Aldehydes, 1,3-Dicarbonyl Compounds, and 6-Aminouracils

被引：15
|
作者：
Lu, Guo-ping [1 ]
Cai, Chun [1 ]
机构：
[1] Nanjing Univ Sci & Technol, Coll Chem Engn, Nanjing 210094, Jiangsu, Peoples R China
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2014年 / 51卷 / 06期
关键词：
ORGANIC-SYNTHESIS; MULTICOMPONENT REACTIONS; NATURAL-PRODUCTS; ATOM ECONOMY; DNA; INHIBITORS; URACIL; DESIGN;
D O I：
10.1002/jhet.1704
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot, efficient protocol for the synthesis of polyfunctionalized pyrido[2,3-d]pyrimidines and uncyclized adducts by 6-aminouracils in poly(ethylene glycol) 200/H2O or AcOH was described. An interesting family of pyrido[2,3-d]pyrimidines and uncyclized adducts bearing fused pharmacological active units are prepared. The reaction is free of toxic solvents and catalysts, has simple workup procedure, and has high atom economy, making it more environmentally friendly and suitable for large-scale operations.
引用
收藏
页码：1595 / 1602
页数：8
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