Cytogenetic and fluorescence in situ hybridization studies in a case of anaplastic thyroid carcinoma

被引：10
|
作者：
Roque, L
Soares, J
Castedo, S
机构：
[1] Inst Portugues Oncol, Dept Morphol Pathol, P-1093 Lisboa, Portugal
[2] Fac Med Porto, Porto, Portugal
[3] Inst Portugues Oncol, Dept Med Genet, Porto, Portugal
来源：
CANCER GENETICS AND CYTOGENETICS | 1998年 / 103卷 / 01期
关键词：
D O I：
10.1016/S0165-4608(97)00302-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cytogenetic analysis of a case of anaplastic thyroid carcinoma revealed multiple numerical and structural chromosomal changes, including a der(9) add(9)(p22)hsr(9)(p?). Fluorescence in situ hybridization (FISH) studies performed to identify the genetic nature of this derivative chromosome showed that both the additional material and the hsr region were composed of only chromosome 9 sequences and that the C-ABL oncogene was not one of the genes harbored at the hsr region. We suggest that amplification of gene(s) located at chromosome 9, other than the C-ABL, may play a significant role in anaplastic evolution of thyroid carcinomas. (C) Elsevier Science Inc., 1998.
引用
收藏
页码：7 / 10
页数：4
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