HER2/HER3 heterodimers in prostate cancer: Whither HER1/EGFR?

被引：21

作者：

Freeman, MR ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Childrens Hosp Boston, Urol Dis Res Ctr,Enders Res Labs, Boston, MA 02115 USA

来源：

CANCER CELL | 2004年 / 6卷 / 05期

关键词：

D O I：

10.1016/j.ccr.2004.10.018

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In this issue of Cancer Cell, Mellinghoff et al. (2004) demonstrate that a small molecule inhibitor of the EGF receptor (EGFR) and the HER2/ErbB2/c-Neu kinase blocks signaling to the androgen receptor by a mechanism that involves HER2/HER3 heterodimerization. Surprisingly, the EGFR is peripheral to this signaling mechanism. These results have implications for the design of targeted therapy for hormone-refractory prostate cancer.

引用

页码：427 / 428

页数：2

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