HER2/HER3 heterodimers in prostate cancer: Whither HER1/EGFR?

被引：21
|
作者：
Freeman, MR [1 ]
机构：
[1] Harvard Univ, Sch Med, Childrens Hosp Boston, Urol Dis Res Ctr,Enders Res Labs, Boston, MA 02115 USA
来源：
CANCER CELL | 2004年 / 6卷 / 05期
关键词：
D O I：
10.1016/j.ccr.2004.10.018
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this issue of Cancer Cell, Mellinghoff et al. (2004) demonstrate that a small molecule inhibitor of the EGF receptor (EGFR) and the HER2/ErbB2/c-Neu kinase blocks signaling to the androgen receptor by a mechanism that involves HER2/HER3 heterodimerization. Surprisingly, the EGFR is peripheral to this signaling mechanism. These results have implications for the design of targeted therapy for hormone-refractory prostate cancer.
引用
收藏
页码：427 / 428
页数：2
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