Is Type 2 Diabetes a Glycogen Storage Disease of Pancreatic β Cells?

被引：70
|
作者：
Ashcroft, Frances M. [1 ,2 ]
Rohm, Maria [1 ,2 ]
Clark, Anne [3 ]
Brereton, Melissa F. [1 ,2 ]
机构：
[1] Univ Oxford, Dept Physiol Anat & Genet, Parks Rd, Oxford OX1 3PT, England
[2] Univ Oxford, OXION, Parks Rd, Oxford OX1 3PT, England
[3] Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Churchill Hosp, Oxford OX3 7LJ, England
来源：
CELL METABOLISM | 2017年 / 26卷 / 01期
基金：
欧洲研究理事会; 英国惠康基金;
关键词：
INSULIN-RELEASE; GLUCOSE; METABOLISM; ACCUMULATION; ISLETS; GENE; AUTOPHAGY; SYNTHASE; PHOSPHORYLASE; EXPRESSION;
D O I：
10.1016/j.cmet.2017.05.014
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Elevated plasma glucose leads to pancreatic beta cell dysfunction and death in type 2 diabetes. Glycogen accumulation, due to impaired metabolism, contributes to this "glucotoxicity" via dysregulated biochemical pathways promoting b cell dysfunction. Here, we review emerging data, and re-examine published findings, on the role of glycogen in b cells in normoglycemia and in diabetes.
引用
收藏
页码：17 / 23
页数：7
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