Cytochrome oxidase and neurofilament reactivity in monocularly deprived human primary visual cortex

被引：19

作者：

Duffy, Kevin R. ^{[1
]}

Murphy, Kathryn M.

Frosch, Matthew P.

Livingstone, Margaret S.

机构：

[1] Dalhousie Univ, Life Sci Ctr, Dept Psychol, Halifax, NS B3H 4J1, Canada

[2] McMaster Univ, Dept Psychol, Hamilton, ON L8S 4K1, Canada

[3] Massachusetts Gen Hosp, Dept Pathol, CS Kubik Lab Neuropathol, Boston, MA 02114 USA

[4] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA

来源：

CEREBRAL CORTEX | 2007年 / 17卷 / 06期

关键词：

CO blobs; deprivation; human; neurofilament; ocular dominance columns; primary visual cortex;

D O I：

10.1093/cercor/bhl038

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Previous studies of human primary visual cortex (V1) have demonstrated a significant eye-specific decrease in cytochrome oxidase (CO) staining following monocular enucleation. We have extended these results by examining CO staining and neurofilament labeling in V1 from a patient with long-standing monocular blindness. A pattern of reduced neurofilament reactivity was found to align with pale CO-stained ocular dominance columns. Neurons located within deprived ocular dominance columns were significantly smaller compared with those in nondeprived columns. A spatial analysis of the relationship between CO blobs and ocular dominance columns revealed that both deprived and nondeprived blobs tended to align with the centers of ocular dominance columns.

引用

页码：1283 / 1291

页数：9

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