Loss of neurofilament labeling in the primary visual cortex of monocularly deprived monkeys

被引:19
作者
Duffy, KR [1 ]
Livingstone, MS
机构
[1] Dalhousie Univ, Life Sci Ctr, Dept Psychol, Halifax, NS B3H 4J1, Canada
[2] Harvard Univ, Sch Med, Dept Neurobiol, Boston, MA 02115 USA
关键词
labeling; monocular deprivation; neural connections; neurofilament; reorganization; ocular dominance; V-1;
D O I
10.1093/cercor/bhh214
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Visual experience during early life is important for the development of neural organizations that support visual function. Closing one eye (monocular deprivation) during this sensitive period can cause a reorganization of neural connections within the visual system that leaves the deprived eye functionally disconnected. We have assessed the pattern of neurofilament labeling in monocularly deprived macaque monkeys to examine the possibility that a cytoskeleton change contributes to deprivation-induced reorganization of neural connections within the primary visual cortex (V-1). Monocular deprivation for three months starting around the time of birth caused a significant loss of neurofilament labeling within deprived-eye ocular dominance columns. Three months of monocular deprivation initiated in adulthood did not produce a loss of neurofilament labeling. The evidence that neurofilament loss was found only when deprivation occurred during the sensitive period supports the notion that the loss permits restructuring of deprived-eye neural connections within the visual system. These results provide evidence that, in addition to reorganization of LGN inputs, the intrinsic circuitry of V-1 neurons is altered when monocular deprivation occurs early in development.
引用
收藏
页码:1146 / 1154
页数:9
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