Type I IFN Receptor Regulates Neutrophil Functions and Innate Immunity to Leishmania Parasites

被引:81
|
作者
Xin, Lijun [1 ]
Vargas-Inchaustegui, Diego A. [1 ]
Raimer, Sharon S. [2 ]
Kelly, Brent C. [2 ]
Hu, Jiping [2 ]
Zhu, Leiyi [2 ]
Sun, Jiaren [1 ]
Soong, Lynn [1 ,3 ]
机构
[1] Univ Texas Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA
[2] Univ Texas Med Branch, Dept Dermatol, Galveston, TX 77555 USA
[3] Univ Texas Med Branch, Sealy Ctr Vaccine Dev, Ctr Biodef & Emerging Infect Dis,Dept Pathol, Inst Human Infect & Immun,Sealy Ctr Canc Cell Bio, Galveston, TX 77555 USA
来源
JOURNAL OF IMMUNOLOGY | 2010年 / 184卷 / 12期
基金
美国国家卫生研究院;
关键词
NATURAL-KILLER-CELLS; TRYPANOSOMA-CRUZI; HOST-DEFENSE; MYCOBACTERIUM-TUBERCULOSIS; CUTANEOUS LEISHMANIASIS; LISTERIA-MONOCYTOGENES; BACTERIAL-INFECTION; DENDRITIC CELLS; INTERFERON; MICE;
D O I
10.4049/jimmunol.0903273
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Type I IFNs exert diverse effector and regulatory functions in host immunity to viral and nonviral infections; however, the role of endogenous type I IFNs in leishmaniasis is unclear. We found that type I IFNR-deficient (IFNAR(-/-)) mice developed attenuated lesions and reduced Ag-specific immune responses following infection with Leishmania amazonensis parasites. The marked reduction in tissue parasites, even at 3 d in IFNAR(-/-) mice, seemed to be indicative of an enhanced innate immunity. Further mechanistic analyses indicated distinct roles for neutrophils in parasite clearance; IFNAR(-/-) mice displayed a rapid and sustained infiltration of neutrophils, but a limited recruitment of CD11b + Ly-6C + inflammatory monocytes, into inflamed tissues; interactions between IFNAR(-/-), but not wild-type (WT) or STAT1(-/-), neutrophils and macrophages greatly enhanced parasite killing in vitro; and infected IFNAR(-/-) neutrophils efficiently released granular enzymes and had elevated rates of cell apoptosis. Furthermore, although coinjection of parasites with WT neutrophils or adoptive transfer of WT neutrophils into IFNAR(-/-) recipients significantly enhanced infection, the coinjection of parasites with IFNAR(-/-) neutrophils greatly reduced parasite survival in WT recipients. Our findings reveal an important role for type I IFNs in regulating neutrophil/monocyte recruitment, neutrophil turnover, and Leishmania infection and provide new insight into innate immunity to protozoan parasites. The Journal of Immunology, 2010, 184: 7047-7056.
引用
收藏
页码:7047 / 7056
页数:10
相关论文
共 50 条
  • [21] Distinct contributions of Type I and Type III IFNs in innate fungal immunity
    Espinosa, Vanessa
    Dutta, Orchi
    Mc Elrath, Constance
    Du, Peicheng
    Chang, Yun-Juan
    Cicciarelli, Bryan
    Pitler, Amy
    Whitehead, Ian
    Obar, Joshua J.
    Durbin, Joan
    Kotenko, Sergei
    Rivera, Amariliz
    JOURNAL OF IMMUNOLOGY, 2020, 204 (01):
  • [22] Type I and type II Fc receptors regulate innate and adaptive immunity
    Andrew Pincetic
    Stylianos Bournazos
    David J DiLillo
    Jad Maamary
    Taia T Wang
    Rony Dahan
    Benjamin-Maximillian Fiebiger
    Jeffrey V Ravetch
    Nature Immunology, 2014, 15 : 707 - 716
  • [23] Type I and type II Fc receptors regulate innate and adaptive immunity
    Pincetic, Andrew
    Bournazos, Stylianos
    DiLillo, David J.
    Maamary, Jad
    Wang, Taia T.
    Dahan, Rony
    Fiebiger, Benjamin-Maximillian
    Ravetch, Jeffrey V.
    NATURE IMMUNOLOGY, 2014, 15 (08) : 707 - 716
  • [24] Phospholipid scramblase-1 regulates pulmonary type 2 innate immunity
    Rothenberg, Marc E.
    Bousquet, Jean
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE, 2023, 152 (03): : 600 - 600
  • [25] Tissue-type plasminogen activator regulates macrophage activation and innate immunity
    Mantuano, Elisabetta
    Azmoon, Pardis
    Brifault, Coralie
    Banki, Michael A.
    Gilder, Andrew S.
    Campana, Wendy M.
    Gonias, Steven L.
    BLOOD, 2017, 130 (11) : 1364 - 1374
  • [26] Upregulation of type I interferon receptor by IFN-γ
    Mizukoshi, E
    Kaneko, S
    Yanagi, M
    Ohno, H
    Matsushita, E
    Kobayashi, K
    JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 1999, 19 (09): : 1019 - 1023
  • [27] IL-21/type I interferon interplay regulates neutrophil-dependent innate immune responses to Staphylococcus aureus
    Spolski, Rosanne
    West, Erin E.
    Li, Peng
    Veenbergen, Sharon
    Yung, Sunny
    Kazemian, Majid
    Oh, Jangsuk
    Yu, Zu-Xi
    Freeman, Alexandra F.
    Holland, Stephen M.
    Murphy, Philip M.
    Leonard, Warren J.
    ELIFE, 2019, 8
  • [28] The Aryl Hydrocarbon Receptor Regulates Gut Immunity through Modulation of Innate Lymphoid Cells
    Qiu, Ju
    Heller, Jennifer J.
    Guo, Xiaohuan
    Chen, Zong-ming E.
    Fish, Kamonwan
    Fu, Yang-Xin
    Zhou, Liang
    IMMUNITY, 2012, 36 (01) : 92 - 104
  • [29] Cholesterol Regulates Innate Immunity via Nuclear Hormone Receptor NHR-8
    Otarigho, Benson
    Aballay, Alejandro
    ISCIENCE, 2020, 23 (05)
  • [30] Innate myeloid signaling for Type I IFN-dependent suppression of EAE
    Khorooshi, Reza
    Wais, Vian
    Dieu, Rythe
    Webster, Gill
    Owens, Trevor
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2017, 86 (04) : 252 - 252