Lack of association between antipsychotic-induced extrapyramidal symptoms and polymorphisms in dopamine metabolism and transport genes

被引：12
|
作者：
Gasso, Patricia
Mas, Sergi
Crescenti, Anna
Alvarez, Santi
Parramon, Gemma [2 ]
Garcia-Rizo, Clemente [2 ]
Parellada, Eduard [2 ]
Bernardo, Miquel [2 ]
Lafuente, Amalia [1 ]
机构：
[1] Univ Barcelona, IDIBAPS, Dept Anat Pathol Pharmacol & Microbiol, E-08036 Barcelona, Spain
[2] Hosp Clin Barcelona, Psychiat Serv, Barcelona, Spain
来源：
PSYCHIATRY RESEARCH | 2010年 / 175卷 / 1-2期
关键词：
Pharmacogenetics; Extrapyramidal symptoms; Antipsychotic; SCHIZOPHRENIC-PATIENTS; MONOAMINE-OXIDASE; CYP2D6; GENOTYPE; POPULATION; RECEPTOR; THERAPY; VNTR;
D O I：
10.1016/j.psychres.2009.07.006
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
The purpose of this study was to investigate the relationship between functional polymorphisms in genes coding for dopamine metabolism and transport enzymes and the incidence of acute antipsychotic (AP)-induced extrapyramidal symptoms (EPS). We did not find evidence of the involvement of these polymorphisms in the predisposition towards or protection from EPS. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：173 / 175
页数：3
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