Novel Exocyclic Nucleoside Related to Clitocine: A Convergent Synthesis of 3′-Azido-2′,3′-dideoxy Clitocine

被引：6

作者：

Guo, Xianghai ^{[1
,2
]}

Liu, Can ^{[3
]}

Zheng, Lanxi ^{[3
]}

Jiang, Shende ^{[3
]}

Shen, Jiaxiang ^{[3
]}

机构：

[1] Tianjin Univ, Minist Educ, Key Lab Syst Bioengn, Tianjin 300072, Peoples R China

[2] Tianjin Univ, Dept Pharmaceut Engn, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China

[3] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin 300072, Peoples R China

来源：

SYNLETT | 2010年 / 13期

关键词：

nucleoside analogues; exocyclic nucleosides; convergent synthesis; clitocine; antiviral drug; POTENTIAL ANTIVIRAL DRUGS; INSECTICIDAL NUCLEOSIDE; CARBOCYCLIC CLITOCINE; AMINO NUCLEOSIDE; ADENOSINE KINASE; ANALOGS; INVERSA; OLIGONUCLEOTIDE; INHIBITORS; CELLS;

D O I：

10.1055/s-0030-1258503

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a new clitocine derivative was achieved through a convergent strategy. A protected 4,6-diamino-5-nitropyrimidine was condensed with p-chlorobenzoyl (PCB)-protected methyl 3'-azido-2',3'-dideoxyribofuranoside, followed by subsequently deprotection to give the desired product.

引用

页码：1959 / 1962

页数：4

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