CANCER THERAPY Targeting drug-resistant mutations in ALK

被引：3

作者：

He, Liu ^{[1
,2
]}

Dar, Arvin C. ^{[1
,2
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Oncol Sci, Tisch Canc Inst, Mt Sinai Ctr Therapeut Discovery, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Dept Pharmacol Sci, Tisch Canc Inst, Mt Sinai Ctr Therapeut Discovery, New York, NY 10029 USA

来源：

NATURE CANCER | 2022年 / 3卷 / 06期

关键词：

INHIBITOR;

D O I：

10.1038/s43018-022-00390-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Therapy resistance limits the clinical success of tyrosine kinase inhibitors (TKIs) in ALK-positive non-small cell lung cancer. A study now proposes a framework to identify compound resistance mutations to the lorlatinib TKI and provides structure-based drug design approaches to overcome resistance mediated by ALK(G1202R) or ALK(I1171N/S/T).

引用

页码：659 / 661

页数：3

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