NOVEL SMALL MOLECULE HPK1 INHIBITOR PCC-1 INDUCES STRONG ANTI-TUMOR ACTIVITY

被引：0

作者：

Das, Sanjib ^{[1
]}

Mandadi, Sravan ^{[1
]}

Saini, Jagmohan ^{[1
]}

Chaudhari, Sachin ^{[1
]}

Deshpande, Ameya ^{[1
]}

Chinnapattu, Murugan ^{[1
]}

Bajpai, Malini ^{[1
]}

Pangre, Priyanka ^{[1
]}

Potdar, Varada ^{[1
]}

Marathe, Megha ^{[1
]}

Sawant, Pooja ^{[1
]}

Akarte, Atul ^{[1
]}

Misra, Chandrasekhar ^{[2
]}

Das, Subhadip ^{[1
]}

Singh, Anuj ^{[1
]}

Das, Avratanu ^{[1
]}

Lambade, Pandurang ^{[1
]}

Tirumalasetty, Chaitanya ^{[1
]}

Patole, Raju ^{[1
]}

Biswas, Nilanjana ^{[1
]}

Karande, Vikas ^{[1
]}

Shah, Heta ^{[1
]}

Behera, Dayanidhi ^{[1
]}

Gowda, Nagaraj ^{[1
]}

Iyer, Pravin ^{[1
]}

机构：

[1] Glenmark Pharmaceut Ltd, Navi Mumbai, India

[2] Glenmark Pharmaceut, Navi Mumbai, India

来源：

JOURNAL FOR IMMUNOTHERAPY OF CANCER | 2021年 / 9卷

关键词：

D O I：

10.1136/jitc-2021-SITC2021.848

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

848

引用

页码：A889 / A889

页数：1

共 50 条

[21] RGT-264 a highly potent, selective and orally bioavailable HPK1 (MAP4K1) inhibitor augments immune activation and anti-tumor immunity
Xiao, F.
Liu, H.
Wu, L.
Feng, S.
Liu, Y.
Xiao, H.
Li, H.
Huang, W.
Ren, X.
Ren, B.
Yao, L.
Lin, J.
Zhong, W.
Xie, Z.
EUROPEAN JOURNAL OF CANCER, 2024, 211 : S172 - S173
[22] An updated review of small-molecule HPK1 kinase inhibitors (2016-present)
Duan, Yiping
Guo, Zhichao
Zhong, Wenyi
Chen, Jichao
Xu, Shengtao
Liu, Jie
Xu, Jinyi
FUTURE MEDICINAL CHEMISTRY, 2024, 16 (22) : 2431 - 2450
[23] Discovery of CRD1601, a potent and selective HPK1 inhibitor with robust in vivo anti-cancer activity
Banerjee, Monali
Shrivastava, Ritesh
Pryde, David
Middya, Sandip
Debnath, Sabyasachi
Middya, Anindita
Yadav, Dharmendra
Rawat, Nidhi
Ghosh, Rajib
Padaliya, Manisha
Basu, Sourav
Surya, Arjun
CANCER RESEARCH, 2024, 84 (06)
[24] Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody
Zeng, Shenxin
Wu, Mingfei
Jin, Yuyuan
Ye, Yingqiao
Xia, Heye
Chen, Xinyi
Che, Jinxin
Wang, Zunyuan
Wu, Ying
Dong, Xiaowu
Chen, Yinqiao
Huang, Wenhai
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 267
[25] An Oral PROTAC Targeting HPK1 Degradation Potentiates Anti-Solid Tumor Immunity
Yao, Yuejun
Wu, Mingfei
Wang, Yanfang
Liao, Ziyan
Yang, Yinxian
Liu, Yun
Shi, Jiaqi
Wu, Wei
Wei, Xinwei
Xu, Jianchang
Guo, Yugang
Dong, Xiaowu
Che, Jinxin
Wang, Jinqiang
Gu, Zhen
ADVANCED MATERIALS, 2024,
[26] Identification of a novel GLUT1 inhibitor with in vitro and in vivo anti-tumor activity
Chen, Xiaotong
Zhao, Yunshuo
He, Chuanjie
Gao, Guanfei
Li, Jiao
Qiu, Lu
Wang, Xiaoxi
Gao, Yanfeng
Qi, Yuanming
Sun, Kai
Du, Jiangfeng
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2022, 216 : 768 - 778
[27] A highly selective and potent HPK1 inhibitor enhances immune cell activation and induces robust tumor growth inhibition in a murine syngeneic tumor model
Ciccone, D.
Lazari, V.
Linney, I.
Briggs, M.
Carreiro, S.
Waddell, I.
Hill, C.
Loh, C.
Tummino, P.
Collis, A.
Kaila, N.
EUROPEAN JOURNAL OF CANCER, 2020, 138 : S20 - S20
[28] A selective HPK1 inhibitor FB849 reprograms intratumoral immune cells and elicits strong anti-cancer immunity
Kim, Hyekyoung
Lim, Seungmook
Park, A. Yeong
Lee, Jinhwa
Kim, Jamie Jae Eun
Jeon, Seung Hyuck
Lee, Yong Joon
Shin, Eui-Cheol
Kim, Seongkon
CANCER RESEARCH, 2024, 84 (06)
[29] GRC 54276, a novel small molecule inhibitor of HPK1 has entered phase 1/2 clinical trial insolid malignancies and Hodgkin's/non Hodgkin's lymphoma
Mandadi, Sravan
Das, Sanjib
Bajpai, Malini
Saini, Jagmohan
Chinnapattu, Murugan
Patale, Sanjay
Patil, Sandip
Kadlag, Nanasaheb
Waghmare, Nayan
Gavhane, Balasaheb
Deshpande, Ameya
Dahale, Dnyaneshwar
Kattige, Vidya
Pangre, Priyanka
Singh, Namrata
Kashyap, Ekta
Marathe, Megha
Mani, Jiju
Akarte, Atul
Misra, Chandrasekhar
Das, Subhadip
Singh, Anuj
Lambade, Pandurang
Das, Avratanu
Tirumalasetty, Chaitanya
Patole, Raju
Biswas, Nilanjana
Karande, Vikas
Shah, Heta
Behera, Dayanidhi
Jain, Pankaj
Sancheti, Pavankumar
Pawar, Pramod
Kr, Vinod
Udupa, Venkatesha
Chaudhari, Sachin S.
Gowda, Nagaraj
Iyer, Pravin S.
CANCER RESEARCH, 2023, 83 (07)
[30] A HIGHLY SELECTIVE AND POTENT HPK1 INHIBITOR ENHANCES IMMUNE CELL ACTIVATION AND INDUCES ROBUST TUMOR GROWTH INHIBITION IN A MURINE SYNGENEIC TUMOR MODEL
Ciccone, David
Lazari, Vad
Linney, Ian
Briggs, Michael
Carreiro, Samantha
McElwee, Joshua
Waddell, Ian
Hill, Chris
Loh, Christine
Tummino, Peter
Collis, Alan
Kaila, Neelu
JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2020, 8 : A411 - A411

← 1 2 3 4 5 →